CHITOSAN USP

WHAT CAN CHITOSAN DO?

As the only cationic (positively charged) molecule in nature, chitosan possesses a unique ability to interact with many types of human cells due to their naturally anionic (negatively charged) properties.

Wound Care/Dressing: Compared to conventional synthetic antibiotics, the antimicrobial properties of chitosan molecule make it an excellent starting material for wound care and wound dressing applications—mitigating infection/inflammation while also promoting healing

Topical/Trauma Hemostats: By interacting with negatively charged skin membranes to initiate agglutination of the red blood cells/platelets, chitosan activates the clotting pathway and leads to thrombus (clot) formation.

Drug Excipient: In pharmaceuticals, chitosan can be used as a tablet binder—assisting in tablet strength and reducing tablet friability. As a disintegrant, chitosan assists tablet breakdown and release of active ingredients more quickly in the digestive tract. As a coating agent, chitosan can mask unpleasant tastes/odors, prevent moisture uptake and improve stability.

Liposome Encapsulation: When using liposomes to deliver therapy, research demonstrates that coating them with chitosan (“chitosomes”) improves their solubility/formulation, reduces “leakage” of the active ingredient and reduces degradation.

Nanoparticles: Nanoparticles manufactured from chitosan (or derivative forms) can provide drug delivery systems across different methods of administration, utilizing its mucoadhesive property to release active ingredients in a controlled, sustained manner.

Tissue Engineering: Chitosan can be used to fabricate scaffolds, gels and membranes to repair/regenerate a variety of tissue (myocardial, musculoskeletal, nervous, etc.). Within these structures, chitosan can also deliver active ingredients and slow the release of therapeutics.

What is the DDA:   Broadly speaking, chitosan is derived by removing acetyl groups from a chitin molecule. A chitosan product’s degree of deacetylation (DDA) refers to the total percentage of acetyl groups which have been removed during formulation (usually between 70% and 95%). DDA is the most common differentiator between chitosan products, and trū Chitosan is capable of creating formulations across the full deacetylation spectrum according to your needs.

Not just chitosan: true medical-grade, medical-application chitosan.  Many suppliers offer “research only” or “medical-grade” chitosan, but there are no official quality standards for chitosan grades. There is, however, the United States Pharmacopeia – National Formulary monograph: the recognized standard for medical applications of the chitosan molecule.

trū Chitosan conform to all USP-NF monograph specifications, it also provides chitosan product options that meet USP 232 Limits of Elemental Impurities for Drug Substances for cutaneous, oral, parenteral, and inhalant delivery. trū Chitosan is produced with FDA requisite cGMP’s with traceable, single-source raw material and manufactured in an FDA-registered facility. The USP monograph and USP 232 quality standards ensure consistent behavior, uncompromising safety and reliable peace of mind.

When your painstakingly conducted research or meticulously crafted pharmaceutical or medical device requires an FDA qualified and consistent behaving and performing chitosan, why would you trust anything less than trū Chitosan?

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